A family with syndactyly type II (synpolydactyly)

Abstract
Syndactyly Type II is reported in 8 members of a family in 4 generations. Affected individuals show 2 distinctive patterns of variation in the expression of the gene. Distortion of dermatoglyphic patterns is associated with the severe but not the mild manifestation of the malformation. The diagnostic significance of minimal features of the condition is discussed. Linkage data suggest that loci for Syndactyly II and for blood-group antigens ABO, MNSs, P, Rh and Kell are not closely linked.