Correlation between spontaneous metastatic potential, platelet-aggregating activity of cell surface extracts, and cell surface sialylation in 10 metastatic-variant derivatives of a rat renal sarcoma cell line.

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Abstract
Several properties of 10 cell lines derived from the polyoma-induced PW20 Wistar-Furth rat renal sarcoma were examined, including the ability of the tumor cells to metastasize spontaneously from subcutaneous sites in syngeneic hosts, the platelet-aggregating activity of material extracted by urea from the surface of cultured cells, the sialic acid content of the platelet-aggregating material and the degree of sialylation of cell surface glycoconjugates in cultured cells. A correlation was observed among all of these parameters. The degree of cell surface sialylation of tumor cells, their ability to aggregate platelets, and their ability to metastasize may be linked.