Cystometrical and in Vitro Evaluation of Urinary Bladder Function in Rats with Streptozotocin-Induced Diabetes
- 1 June 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 139 (6) , 1359-1362
- https://doi.org/10.1016/s0022-5347(17)42919-3
Abstract
Micturition pattern and cystometric characteristics were determined in control rts, and in rats with streptozotocin-induced diabetes (six weeks duration). The diabetic rats had an increased frequency of micturition, an increased micturition volume, and an increased 24 hr. urinary output. The cystometry showed that the diabetic bladders had an increased compliance and a higher threshold volume for initating a micturition reflex. No spontaneous rhythmic contractions were seen during the filling phase, and no residual urine could be detected. While micturition pressure increased, the micturition time was virtually unaltered. In vitro a right-ward shift for passive and active length-tension relations were noted. The observed changes in cystometric characteristics and length-tension relations might probably be explained on the basis of adaptive changes to the increased diuresis involving both sensory and motor control of the urinary bladder.This publication has 15 references indexed in Scilit:
- Cystometrical Evaluation of Bladder Instability in Rats with Infravesical Outflow ObstructionJournal of Urology, 1987
- Electrophysiologic tests of bladder innervation as indicators of autonomic neuropathy in diabetes mellitusNeurourology and Urodynamics, 1987
- ATROPINE AND MICTURITION RESPONSES BY RATS WITH INTACT AND PARTIALLY INNERVATED BLADDERBritish Journal of Pharmacology, 1981
- Diagnosis of Urinary Bladder Dysfunction in Diabetes MellitusAnnals of Internal Medicine, 1980
- Development of Urinary Bladder Dysfunction in Diabetes MellitusAnnals of Internal Medicine, 1980
- The Diabetic BladderProceedings of the Royal Society of Medicine, 1974
- Asymptomatic neurogenic bladder in juvenile diabeticsDiabetologia, 1971
- The Significance of Deficient Bladder SensationJournal of Urology, 1968
- Urinary Bladder Disturbances in Diabetics: I. A Comparative Study of Male Diabetics and Controls Aged between 20 and 50 YearsScandinavian Journal of Urology and Nephrology, 1967
- Neurogenic Disorders of the Bladder in Diabetes MellitusActa Medica Scandinavica, 1966