Threshold Pco2 dependence on arterial pH for the respiratory system of dogs

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Abstract
By observing respiratory discharges of the phrenic nerve, the threshold values of Pco2 (Ptco2) as chemical stimulus for the respiratory system were examined at varying arterial pH's on anesthetized dogs with and without vagotomy. 1) The reliability of the Ptco2 obtained by this method was high, the standard deviation being 0.48 mm Hg of Pco2. 2) The Ptco2 was lowered as the arterial cH (Ht) was increased by ammonium chloride infusion. The relationship between the Ptco2 and the Ht was linear and the regression line was calculated to be Ptco2 + 0.429 Ht = 44.0 for vagotomized and Ptco2 + 0.361 Ht = 46.1 for nonvagotomized dogs. 3) By combining this equation with that previously obtained expressing the partial effect of increased arterial cH and Pco2 on alveolar ventilation ratio (VR), the general chemical stimulation equation for ventilation in anesthetized normal dogs was derived to be VR = 0.194 Pco2 + 0.071 H – 8.94. 4) The Ptco2 of vagotomized dogs was several millimeters Hg lower than that of nonvagotomized dogs. Submitted on April 23, 1962

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