The N-oxidation of benzamidines in vitro
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 13 (8) , 467-473
- https://doi.org/10.3109/00498258309052286
Abstract
1. The enzymic N-oxidation of a series of N-unsubstituted basic benzamidines (I) to a new type of metabolite, the amidoximes (II), is reported. 2. Rabbit liver homogenates (9000g supernatant) were used as enzyme source, and metabolites were identified by t.l.c. and mass spectral analysis using synthetic reference compounds. 3. The microsomal NADPH- and oxygen-dependent hydroxylation of benzamidines was not detected after incubation of benzamidine in the presence of SKF 525-A, a known inhibitor of cytochrome P-450. 4. Neither benzamidine or p-methoxybenzamidine is a good substrate for purified microsomal FAD-containing mono-oxygenase.This publication has 23 references indexed in Scilit:
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