EVALUATION OF TISSUE INGROWTH INTO EXPERIMENTAL REPLAMINEFORM VASCULAR PROSTHESES - PRELIMINARY-REPORT

  • 1 January 1976
    • journal article
    • research article
    • Vol. 79  (2) , 229-232
Abstract
A new experimental arterial prosthesis was developed by replacing the minimal surface microporous calcite structure of sea urchin spines. Prostheses having a 4 mm inside diameter and a homogenous 15-20 .mu. porous network were prepared in bioelectric polyurethane and segmented polyurethane. Prostheses (10) were placed in the femoral and carotid arteries of dogs weighing 27-35 kg and were harvested at a time interval of 3-14 days to characterize the tissue ingrowth. Of the 10 prostheses 8 were widely patent at time of harvest, with tissue ingrowth evident as early as the 3rd day and with complete fibroblastic and capillary penetration of the 1 mm thick walls developed by the end of 1 wk. By 2 wk there was uniform formation of 50-100 .mu. well organized neointimal surfaces.

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