OCULAR COMPLICATIONS IN THE RAT MADE DIABETIC WITH ALLOXAN

1 October 1952

journal article
research article
Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)

Vol. 48 (4) , 414-419
https://doi.org/10.1001/archopht.1952.00920010423003

Abstract

CATARACTS in rats made diabetic by pancreatectomy were observed by Foglia and Cramer¹in 1944, and in the same year Bailey, Bailey, and Leech²reported cataracts in rats made diabetic with alloxan. Since these earlier studies, many investigators have obtained cataracts in diabetic rats. Most workers have pointed out that high blood sugar levels are imperative for cataract formation. This has been stressed in the recent publications of Sterling and Day³and Patterson.⁴By altering experimental diets, mainly by reducing the carbohydrate content, Charalampous and Hegsted⁵and Rodriguez and Krehl⁶have prevented cataract formation or delayed its onset in the diabetic rat. Kok-van Alphen⁷found that if the diabetes in the rat was controlled with insulin, cataract failed to develop. The work cited demonstrates that cataract occurs either because of failure of the lens to metabolize glucose or because the high aqueous sugar

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