The Use of Synthetic Oxytocin in Nursing or Non-Nursing Mothers

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Abstract
The possibility of administering oxytocin by nasal spray, either to inhibit lactation or to assist it, was investigated in 393 mothers. The 165 nursing mothers sprayed each nostril immediately before the baby nursed, while the 228 non-nursing mothers used the spray as desired to prevent pain or engorgement. The desired effect, the letdown of accumulated milk, was ascribed to the action of oxytocin in stimulating the involuntary musculature of the peripheral breast tissue to contract and so to force the milk into the larger ducts of the central portion of the breast, whence it was readily discharged. Good or fair results were obtained in all but 20 of the nursing and all but 10 of the non-nursing mothers, and no evidence of untoward reactions was observed in any of the patients studied.

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