PHARMACOKINETICS OF ALTHESIN-COMPARISON WITH LIGNOCAINE

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Abstract
The plasma concentrations of alphaxalone were measured with a gas chromatographics technique in six patients following a single i.v. injection of Althesin, and in five volunteers following oral administration. A two-compartment open model was used in five volunteers following oral administation. A two-compartment open model was used in the pharmacokinetics analysis of the data, and with the plasma clearance of alphaxalone was similar to the blood flow through the liver. A comparison with the pharmacokinetics of lignocaine was made.

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