Analysis of the CCL3-L1 gene for association with HIV-1 susceptibility and disease progression
- 1 April 2004
- journal article
- research article
- Published by Wolters Kluwer Health in AIDS
- Vol. 18 (7) , 1069-1071
- https://doi.org/10.1097/00002030-200404300-00017
Abstract
CCL-L1 binds more potently to CCR5 than any other chemokine; it inhibits HIV-1 infection in vitro, and its gene occurs in variable copy numbers, some individuals failing to produce it. We analysed the frequency of the absence of CCL3-L1 in 268 Caucasian Australian HIV-1 patients and 260 uninfected individuals. A CCL-L1-negative genotype frequency of 2.3% was found in HIV-1 negative individuals. No association was found between the absence of CCL3-L1 and susceptibility to, or rate of progression of, HIV-1 infection.Keywords
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