TRIMETHYLCOLCHICINIC ACID IN THE TREATMENT OF ACUTE GOUT
- 1 February 1961
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 54 (2) , 274-279
- https://doi.org/10.7326/0003-4819-54-2-274
Abstract
Trimethylcolchicinic acid, an analog of colchicine, was used in the treatment of 34 patients with acute gout, in doses ranging from 5 to 16 mg. Twenty-six responded well, and an additional 4 patients had partial benefit. Four patients did not respond at all. Mild nausea or diarrhea in 3 patients were the only side effects noted. No hematologic, cutaneous or other signs of toxicity were seen. Seven additional patients received short term, small dose prophylactic therapy with trimethylcolchicinic acid. No cumulative toxicity was seen.Keywords
This publication has 5 references indexed in Scilit:
- Colchicine Alopecia11From the Section of Dermatology, Department of Medicine, University of Chicago, Chicago, Ill.Journal of Investigative Dermatology, 1959
- Damage Induced in Sarcoma 37 with Chemical Agents, III. Colchicine Derivatives Related to Trimethylcolchicinic Acid and to Colchinol2JNCI Journal of the National Cancer Institute, 1952
- Studies on colchicine derivatives.I. Toxicity in mice and effects on mouse sarcoma 180Cancer, 1950
- Studies on colchicine derivatives.II. Effect on mitotic activity of the corneal epitheliumCancer, 1950
- Mitotic Response to Colchicine in Human Cancer.Experimental Biology and Medicine, 1947