Persistent Increase in Brain Serotonin Turnover after Chronic Administration of LSD in the Rat
- 1 October 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 174 (4004) , 62-64
- https://doi.org/10.1126/science.174.4004.62
Abstract
Lysergic acid diethylamide at doses of 20 micrograms per kilogram per day was administered orally to rats for 1 month. Eighteen hours after the final dose a 25 to 30 percent increase in the synthesis and turnover of serotonin was noted, as well as a moderate but significant increase in the concentration of tryptophan (18 percent) and serotonin (13 percent) in the brain.Keywords
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