Effect of Combined Thyroxin-Cortisone-Growth Hormone Therapy on Hematopoiesis in Hypophysectomized Rats.

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Abstract
Previous work has shown that a combined thyroxin-cortisone therapy in hypophysectomized rats will eliminate the anemia and induce a marked decrease in peripheral white cells; this is accompanied by a severe hypoplasia of the bone marrow. In addition, growth hormone increases the peripheral white cell count in hypophysectomized rats but has no effect on the peripheral anemia; the bone marrow is hyperplastic. Adding growth hormone to the thyroxin-cortisone therapy resulted in repair of post-hypophysectomy anemia, in normal histological appearance of bone marrow, in normal total number of cells/mm3 of marrow tissue, and in values for myeloid elements/mm3 of marrow and peripheral white cells slightly above normal. The values for erythroid elements/mm3 of marrow averaged 82% of normal. These hematological findings were accompanied by a normal O2 consumption.