HLA‐B27 and the pathogenesis of spondyloarthritis
- 1 September 2002
- journal article
- review article
- Published by Wiley in Tissue Antigens
- Vol. 60 (3) , 191-205
- https://doi.org/10.1034/j.1399-0039.2002.600301.x
Abstract
The association of HLA‐B27 with ankylosing spondylitis and other spondyloarthropathies ranks among the strongest between any HLA antigen and a human disease. Yet, in spite of intense research and advanced knowledge of the biochemistry and biology of major histocompatibility complex molecules, the mechanism of this association remains unknown. This review attempts a critical assessment of current pathogenetic hypotheses from evidence concerning the epidemiology of HLA–B27 association with disease, its peptide‐binding specificity, and other aspects of the molecular biology and immunology of this molecule.Keywords
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