Effect of oral amrinone on platelet function and survival

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Abstract
Amrinone is a cardiotonic agent associated with reversible thrombocytopenia in 20%-50% of patients. The mechanism of thrombocytopenia is not known and it is not clear whether this effect represents a high-frequency idiosyncratic reaction or an overt manifestation of a toxic effect on platelet survival. The effect of oral amrinone on platelet function and survival in 7 subjects who participated in a clinical trial of chronic oral amrinone therapy was evaluated. There was no consistent effect on either platelet function or platelet survival. Amrinone apparently does not have a uniform effect on platelet survival and the development of thrombocytopenia may represent an idiosyncratic reaction.