Cyclosporin A Treatment in a Case of Relapsing Polychondritis

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Abstract
A patient with relapsing polychondritis and high titers of anti-collagen II antibodies developed a progressive destruction of tracheal cartilage in spite of treatment with corticosteroids, Dapsone, Azathioprine and cyclophosphamide. Assumptions regarding the role of anti-collagen immunity, together with immunohistochemical studies on affected cartilage, suggested macrophage-T cell interactions to be important in the pathogenesis of the disease. Cyclosporin A treatment was instituted and has been continued for 2 yr, concomitant with a steady improvement and remission of the disease.