Clues to the Pathogenesis of Bleeding in von Willebrand's Disease

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Abstract
RECENT studies have demonstrated that the plasma of patients with classic hemophilia, deficient in functional antihemophilic factor (AHF), contains normal or elevated amounts of antigenic material related to AHF.1 2 3 4 In patients with classic hemophilia, the bleeding time is normal, and when whole blood is filtered through glass beads, a normal proportion of platelets is retained. In contrast, the plasma of patients with von Willebrand's disease is deficient both in functional AHF activity and in antigens related to AHF.3 , 4 In most patients with von Willebrand's disease, the bleeding time is prolonged, and platelet retention by columns of glass beads is deficient. . . .