Daunomycin-arachidonic acid complex as a potential new antitumor agent
- 1 August 1984
- journal article
- research article
- Published by Springer Nature in Cancer Chemotherapy and Pharmacology
- Vol. 13 (2) , 75-77
- https://doi.org/10.1007/bf00257117
Abstract
A daunomycin-arachidonic acid complex (DM-C20:4) administered IV had a marked antitumor effect on the intraperitoneal growth of the AFP-producing hepatoma cell line, AH66. However, the daunomycin-arachidic acid (DM-C20:0) saturated fatty acid complex showed only the same antitumor effect on the AH66 cells as free daunomycin. It was demonstrated that the DM-C20:4 preparation maintained its chemical properties for some time in both plasma and liver homogenate.This publication has 2 references indexed in Scilit:
- Antibody-Linked Cytotoxic Agents in the Treatment of Cancer: Current Status and Future Prospects2JNCI Journal of the National Cancer Institute, 1978
- The presence of fatty acids in human alpha-fetoprotein.Journal of Biological Chemistry, 1978