Inhibition of Estradiol-Induced Pituitary Hypertrophy in Rats.

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Abstract
The three estrogens, estradiol, stilbestrol and tri-p-anisyl chloroethylene (TACE) were compared for their adrenal and pituitary effects in rats. Equi-potent doses of estradiol caused greater pituitary enlargement than stilbestrol. TACE caused no enlargement whatsoever. When 2 estrogens were given concurrently there was a competitive, rather than an additive action. With all estrogens there was evidence for ACTH-stimulated adrenal hyperactivity, determined by increase in adrenal weight and thymus gland involution.