Influence of Unsaturation on Fibrinolytic Activity of Salts of Fatty Acids

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Abstract
We have found that sodium or potassium salts of some long chain fatty acids induce fibrinolytic activity on unheated bovine fibrin films. The influence of chain length and unsaturation on ability to induce fibrinolysis has been studied. Unsaturated fatty acids seem to be more active than the saturated compounds. The presence of one unsaturated bond appears to make little difference in activity of C16 fatty acids. In C18 and C20 acids, it increases activity roughly 10-fold. In C22 and C24 acids, it increases activity more than 100-fold. A possible role of fatty acids in regulation of fibrin formation and digestion is suggested.

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