Vesicoureteral Reflux in the Primate: II. Maturation of the Ureterovesical Junction

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Abstract
Infant rhesus monkeys frequently show vesicoureteral reflux unlike adults. Monkeys born of mothers who were on normal or protein-deficient diets were studied. Protein deficiency may influence the time that reflux continued, but this was not statistically proved. Reflux disappeared over time. The time was influenced by when the pregnancy was initiated and the maturity of the infant. Maturation as measured by skeletal maturity scores correlated well with the time of reflux, but growth as measured by birth weight did not. Vesicoureteral reflux in the monkey was frequent, but maturation of the ureterovesical junction occurs by 3 yr of age and reflux disappeared.