Delta-9-Tetrahydrocannabinol: Localization in Body Fat
- 26 January 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 179 (4071) , 391-393
- https://doi.org/10.1126/science.179.4071.391
Abstract
[14C]Δ9-Tetrahydrocannabinol (Δ9THC) was injected subcutaneously in rats every day for 1 to 26 days. Concentrations of Δ9THC and its metabolites, 11-hydroxytetrahydrocannabinol and 8,11-dihydroxytetrahydrocannabinol, were determined in various tissues. After a single injection, the concentration of Δ9THC in fat was ten times greater than in any other tissue examined, and persisted in this tissue for 2 weeks. With repeated injection, Δ9THC and its metabolites accumulated in fat and brain.Keywords
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