Microvascular Haemostasis and the Effect of Local Stimulation and inhibition of Platelet Function. An Experimental Study in Rabbits
- 1 January 1976
- journal article
- research article
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 36 (01) , 133-139
- https://doi.org/10.1055/s-0038-1648017
Abstract
The local stimulation and inhibition of haemostatic plug formation was studied by local infusion and superfusion of different agents – ADP, thrombin, adenosine, heparin, prostaglandin E1 (PGE1) and laser injury. ADP and laser injury shortened venular haemostatic plug formation time whereas adenosine in the superfusate and PGE1 prolonged it. Thrombin infusion had no effect but thrombin in the superfusate significantly stabilised the haemostatic plugs. It is suggested that ADP released from red cells is the most potent stimulator for haemostatic plug formation in the rabbit mesenteric microcirculation. * Present address: Department of Surgery, Kärnsjukhuset, Skövde, Sweden.This publication has 4 references indexed in Scilit:
- The Function of PlateletsTransfusion, 1966
- THE HAEMOSTATIC MECHANISM IN PATIENTS WITH HAEMORRHAGIC DISEASESActa Pathologica Microbiologica Scandinavica, 1964
- The Ultrastructure of Haemostatic Blood Platelet Plugs in Rabbit MesenteriumThrombosis and Haemostasis, 1962
- Morphology and Enumeration of Human Blood PlateletsJournal of Applied Physiology, 1950