Preparation of 4‐pyrimidinetliiones from acyl lsothiocyanate‐enamine adducts
- 1 February 1969
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 6 (1) , 37-41
- https://doi.org/10.1002/jhet.5570060107
Abstract
Adducts formed from benzoyl isothiocyanate and l‐morpholinocyclopentene or β‐(N,N‐diethylamino)styrene and that prepared from acetyl isothiocyanate and l‐pyrrolidinoeyclopen‐tene gave 4‐pyrimidinethiones when treated with primary amines or ammonia. In some cases intermediates, the products of amine exchange, were isolated. These intermediates were readily cyclized to 4‐pyrimidinethiones with dilute alkali.Keywords
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