The selectivity of the opioid antagonist, naltrindole, for δ-opioid receptors
- 1 May 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 42 (5) , 358-359
- https://doi.org/10.1111/j.2042-7158.1990.tb05428.x
Abstract
In the mouse vas deferens, naltrindole gave pKB values of 9.7, 8.3, and 7.5 at the δ-, μ-, and K-sites and in binding assays, pIC50 values of 9.6, 7.8 and 7.2 at the same sites. The affinity of naltrindole for the δ binding site was increased in the presence of sodium ions and 5′-guanylylimidophosphate. Naltrindole is, thus, a potent opioid antagonist with marked selectivity for the δ-opioid receptor.This publication has 8 references indexed in Scilit:
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