METABOLISM OF ADRENAL STEROIDS IN THE MOUSE: 1. OBSERVATIONS ON 20α-DIHYDROCORTICOSTERONE AND CORTICOSTERONE IN THE PLASMA OF MICE TREATED WITH CORTICOTROPIN

1 January 1956

journal article
Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology

Vol. 34 (1) , 913-918
https://doi.org/10.1139/y56-097

Abstract

Plasma levels of corticosterone and 20α-dihydrocorticosterone increase in the mouse following the administration of corticotropin. These are the two most abundant C₂₁Δ⁴-3-keto adrenal steroids in mouse plasma. The evidence indicates that some, if not all, of the circulating 20α-dihydrocorticosterone represents a tissue metabolite of corticosterone. A procedure is outlined for the synthesis of 20α-dihydrocorticosterone.

Keywords

METABOLITE
TISSUE
ADMINISTRATION
ADRENAL STEROIDS
ABUNDANT
DIHYDROCORTICOSTERONE
OUTLINED

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