Structure of Complement Receptor 2 in Complex with Its C3d Ligand
- 1 June 2001
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 292 (5522) , 1725-1728
- https://doi.org/10.1126/science.1059118
Abstract
Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.Keywords
This publication has 20 references indexed in Scilit:
- B Cells of HIV-1–Infected Patients Bind Virions through Cd21–Complement Interactions and Transmit Infectious Virus to Activated T CellsThe Journal of Experimental Medicine, 2000
- NMR studies of a viral protein that mimics the regulators of complement activationJournal of Molecular Biology, 1997
- Disruption of the Cr2 Locus Results in a Reduction in B-1a Cells and in an Impaired B Cell Response to T-Dependent AntigenPublished by Elsevier ,1996
- The CCP4 suite: programs for protein crystallographyActa Crystallographica Section D-Biological Crystallography, 1994
- Solution Structure of a Pair of Complement Modules by Nuclear Magnetic ResonanceJournal of Molecular Biology, 1993
- CD19: Lowering the Threshold for Antigen Receptor Stimulation of B LymphocytesScience, 1992
- Suppression of the Immune Response by a Soluble Complement Receptor of B LymphocytesScience, 1991
- Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2.The Journal of Experimental Medicine, 1989
- The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigensNature, 1987
- OKB7, a monoclonal antibody that reacts at or near the C3d binding site of human CR2Cellular Immunology, 1985