Increase in weight after treatment with depot neuroleptics

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Abstract
A trial was performed investigating changes in weight in 99 female patients who were treated with clopenthixol decanoate or perphenazine enanthate after prior treatment with different oral neuroleptics. A significantly higher mean weight was found after the oral treatment period and a slight, but not statistically significant, further weight increase after the following depot period. The rate of weight increase was significantly lower during the depot treatment period. These increases might be due to achievement of a steady-state in weight during the 1st treatment period with oral intake. No difference was found between clopenthixol decanoate and perphenazine enanthate as regards weight change or rate of weight change.

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