Acquired Hypogammaglobulinemia in an Adult

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Abstract
SINCE the first descriptions of the syndromes of congenital and acquired hypogammaglobulinemia,1 2 3 ¶ the acquired disease has been reported in 19 adults.4 5 6 7 8 9 10 11 12 13 14 The syndrome consists of extreme susceptibility to infection, low to undetectable levels of circulating antibodies and gamma globulins, immunologic unresponsiveness to antigenic challenge and clinical improvement with replacement gamma-globulin therapy.This paper presents the findings in the oldest reported living patient with the syndrome of acquired hypogammaglobulinemia, together with studies of her immune mechanisms and gamma-globulin metabolism.Case ReportR.E.H., a 63-year-old secretary, was admitted to the Clinical Center of the National Institutes of Health on July 20, 1954, . . .