Parkinsonianlike Signs and Risk of Incident Alzheimer Disease in Older Persons

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Abstract
PARKINSONIANLIKE SIGNS are common in older persons with and without Alzheimer disease (AD).1-5 Literature suggests that the presence of these signs may be associated with an increased risk of developing AD.6 However, recent data suggest that parkinsonianlike signs in older persons are multidimensional (ie, gait disturbance, bradykinesia, rigidity, tremor)7 and often progressive.5 Furthermore, the severity of parkinsonianlike signs assessed at one point in time is not strongly predictive of the rate at which the signs progress.5 This suggests that understanding the relationship of these signs to AD will require information about how progression in different signs is related to the development of AD and its principal manifestation, cognitive decline.