Ceruloplasmin, Transferrin, and Tryptophan in Schizophrenia
- 1 June 1958
- journal article
- other
- Published by American Medical Association (AMA) in Archives of Neurology & Psychiatry
- Vol. 79 (6) , 730-734
- https://doi.org/10.1001/archneurpsyc.1958.02340060128019
Abstract
It has been suggested that the blood of schizophrenic patients contains a toxic factor which may be the cause of some of the symptoms of the disease.1The identity of this compound has not been established. Particularly interesting, however, are the reports which indicate that an indole may be a toxic factor.2There are several theories as to how an unusual indole may arise within the metabolism of the organism. One of the most popular involves the oxidation of epinephrine to some indole-like material.3Heath's study of the oxidation of epinephrine indicates that this substance is oxidized more rapidly by plasma from schizophrenic persons than by that from normal controls.4Other workers have attempted to show that the copper-containing enzyme, ceruloplasmin, catalyzes this oxidation.5Akerfeldt has measured the rates of oxidation ofN,N'-dimethyl-p-phenylenediamine and reported the results as indicative of ceruloplasmin levelsKeywords
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