Specific Inhibition of an Anti-Hapten Immune Response by Chemical Modification of Cells

Abstract
Reaction of mouse spleen cells with 2,4,6-trinitrophenyl sulfonate (TNPS) resulted in suppression of an in vitro anti-TNP antibody response without diminishing the response to carrier sheep red blood cells (SRBC). The anti-TNP response of unreacted spleen cells could also be inhibited specifically by addition of small fractions of TNPS-reacted cells, indicating that the specific inhibition is not primarily due to direct chemical modification by TNPS of anti-TNP cellular receptor sites. These results illustrate some of the considerations involved in applying affinity labeling to the problem of antigen receptors on lymphocytes. They also suggest a general procedure for suppressing a particular antibody response with appropriately modified homologous cells.

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