The Relationship Between Plasma Fluoride, Urinary Excretion Rate and Urine Fluoride Concentration in Man

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Abstract
The fluoride [F-] concentration in urine is commonly used for monitoring F- exposure, e.g., in Al plants. Hitherto this parameter did not seem to have been related to the actual F- concentration in plasma following exposure. The F- concentration in urine, the urinary excretion rate of F- and the F- concentration in plasma were studied in 5 volunteers after intake of 10 mg F- in the form of NaF tablets. In pharmacokinetic analyses of the data calculation of the half-life of F- from plasma data and from the urinary excretion rate yielded almost identical results, 5.78 h (plasma) and 5.11 h (urine). Plasma F- levels were correlated with the F- concentration in urine (r = 0.7532; n = 70), but even more with the urinary excretion rate of F- (r = 0.9651; n = 63). Plasma F- levels or urinary excretion rates of F- may give a more correct picture of occupational F- exposure than F- concentrations in urine.

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