Cannabinoid-based drugs as anti-inflammatory therapeutics
Top Cited Papers
- 1 May 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 5 (5) , 400-411
- https://doi.org/10.1038/nri1602
Abstract
In the nineteenth century, marijuana was prescribed by physicians for maladies ranging from eating disorders to rabies. However, as newer, more effective drugs were discovered and as the potential for abuse of marijuana was recognized, its use as a therapeutic became restricted, and only recently has its therapeutic potential been re-evaluated. Recent studies in animal models and in humans have produced promising results for the treatment of various disorders - such as obesity, cancer, and spasticity and tremor due to neuropathology - with drugs based on marijuana-derived cannabinoids. Moreover, as I discuss here, a wealth of information also indicates that these drugs have immunosuppressive and anti-inflammatory properties; therefore, on the basis of this mode of action, the therapeutic usefulness of these drugs in chronic inflammatory diseases is now being reassessed.Keywords
This publication has 115 references indexed in Scilit:
- The endogenous cannabinoid 2‐arachidonoyl glycerol as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble proteinThe FASEB Journal, 2004
- Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trialBMJ, 2004
- The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent mannerBlood, 2004
- Toll-like receptor signallingNature Reviews Immunology, 2004
- γ-Irradiation Enhances Apoptosis Induced by Cannabidiol, a Non-psychotropic Cannabinoid, in Cultured HL-60 Myeloblastic Leukemia CellsLeukemia & Lymphoma, 2003
- Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significanceProstaglandins, Leukotrienes & Essential Fatty Acids, 2002
- Autocrine and Paracrine Regulation of Lymphocyte CB2 Receptor Expression by TGF-βBiochemical and Biophysical Research Communications, 2002
- Cannabinol Derivatives: Binding to Cannabinoid Receptors and Inhibition of AdenylylcyclaseJournal of Medicinal Chemistry, 1997
- In vitro and in vivo suppressive effects of delta-9-tetrahydrocannabinol on interferon production by murine spleen cellsInternational Journal of Immunopharmacology, 1986
- Isolation, Structure, and Partial Synthesis of an Active Constituent of HashishJournal of the American Chemical Society, 1964