EXPERIMENTAL MALARIA IN MAN. III. THE CHANGES IN THE ELECTROCARDIOGRAM 1

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Abstract
Electrocardiograms (3 standard leads) were recorded from 12 men before blood-induced vivax malaria and on the 2d and 21st days following termination of the disease. On each occasion records were taken in basal rest (supine) and in the 1st, 5th and 10th minutes of passive elevation to 68[degree] on a hip-sling tilt-table. Quantitative analysis showed that 12 out of 14 items measured were significantly changed by malaria, including a general tendency to depression of T and of the ST segment in leads II and III and, in the upright posture, a large shift of the axis to the left. The tilt-table was found useful in revealing changes not apparent from the electrocardiograms recorded in the ordinary supine posture. 21 days after malaria significant alterations from the pre-malaria control persisted in 5 electrocardiographic items. Although most of the changes were statistically highly significant, they occurred within the so-called normal limits.

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