Histocompatibility Antigens in Osgood-Schlatter Disease

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Abstract
Eighteen unrelated children (12 boys and 6 girls) with Osgood-Schlatter disease (OSD) were evaluated by history, physical examination, and histocompatibility antigen [human leukocyte antigen (HLA)] determination. Four boys and 2 girls had pain at sites other than the tibial tuberosity. By history, other related individuals with a diagnosis of OSD were found in 6 of the 18 families. The distributions of HLA antigens (A, B, and DR) were not demonstrably abnormal. The similarity of OSD and enthesitis accompanying HLA-B27-associated arthropathy may cause diagnostic difficulty. The lack of an association between OSD and HLA-B27 may be of assistance in differentiating the 2 disorders.

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