Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm
Top Cited Papers
- 1 March 2003
- journal article
- review article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 370 (2) , 361-371
- https://doi.org/10.1042/bj20021626
Abstract
Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic motif. This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases.Keywords
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