Biosensor Systems in Standard CMOS Processes: Fact or Fiction?

Abstract
In this paper, we discuss the advantages and limitations of using standard complementary metal-oxide-semiconductor (CMOS) fabrication processes for the design of integrated affinity-based biosensor systems. In particular, we examine the compatibility of CMOS with various assaying techniques, detection modalities, and the possibility of fabricating their transducer structures on-chip.

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