PRESENCE OF HOST-REACTIVE T-CELLS IN LYMPHOHEMATOPOIETIC CHIMERAS
- 1 January 1983
- journal article
- research article
- Vol. 48 (2) , 219-227
Abstract
The presence of autoreactive lymphocytes was investigated in murine lymphohematopoietic chimeras. The presence of precursors of host-reactive cytotoxic effector T lymphocytes in parent .fwdarw. F1 chimeras is demonstrated. Lymphocytes from these chimeras display cytotoxic activity towards the nonshared major histocompatibility complex (MHC) antigens of the host following activation with the polyclonal T-cell activator concanavalin A. These host-reactive cells were found despite the apparent absence of lymphocytes demonstrating autoreactivity in other experimental systems: mixed lymphocyte reaction, cell-mediated lympholysis, positive allogeneic effect and negative allogeneic effect. Animals possessing precursors of cytotoxic effector cells also possess precursors of cytotoxic effector cells capable of generating an MHC-restricted anti-minor histocompatibility antigen response. The results are discussed in reference to the role of the thymus in effecting self/non-self discrimination.This publication has 25 references indexed in Scilit:
- Presence of Alloantigen-Reactive Cells in Neonatally Tolerized MiceScandinavian Journal of Immunology, 1978
- On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?The Journal of Experimental Medicine, 1978
- Virus-specific T-cell-mediated cytotoxicity across the H–2 barrier to virus-altered alloantigenNature, 1976
- Lymphocyte-mediated cytotoxicity against tumor cells. III. Differentiation of concanavalin A-activated cytotoxic effector cellsEuropean Journal of Immunology, 1976
- Lymphocyte-mediated cytotoxicity against tumor cells. II. Characteristics and tissue distribution of concanavalin A- activated cytotoxic effector cellsEuropean Journal of Immunology, 1976
- H‐2 antigen‐specific cytotoxic T cells induced by concanavalin A: estimation of their relative frequencyEuropean Journal of Immunology, 1976
- Role of the Murine Major Histocompatibility Complex in the Specificity of in vitro T‐Cell‐Mediated Lympholysis Against Chemically‐Modified Autologous LymphocytesImmunological Reviews, 1976
- Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.The Journal of Experimental Medicine, 1975
- A rapid method for the isolation of functional thymus‐derived murine lymphocytesEuropean Journal of Immunology, 1973
- HUMORAL ANTAGONISM OF CELLULAR IMMUNITY IN CHILDREN WITH IMMUNE-DEFICIENCY DISEASE RECONSTITUTED BY BONE-MARROW TRANSPLANTATIONThe Lancet, 1971