THE CHILDREN OF PARENTS EXPOSED TO ATOMIC BOMBS - ESTIMATES OF THE GENETIC DOUBLING DOSE OF RADIATION FOR HUMANS
- 1 June 1990
- journal article
- research article
- Vol. 46 (6) , 1053-1072
Abstract
The data collected in Hiroshima and Nagasaki during the past 40 year son the children of survivors of the atomic bombings and on the children of a suitable control population are analyzed on the basis of the newly revised estimates of radiation doses. No statistically significant effects emerge with respect to eight different indicators. Since, however, it may confidently be assumed some mutations were induced, we have taken the data at face value and calculated the minimal gametic doubling doses of acute radiation for the individual indicators at various probability levels. An effort has also been made to calculate the most probable doubling dose for the indicators combined. The latter value is between 1.7 and 2.2 Sv. It is suggested the appropriate figure for chronic radiation would be between 3.4 and 4.5 Sv. These estimates suggest humans are less sensitive to the genetic effects of radiation than has been assumed on the basis of past extrapolations from experiments with mice.This publication has 38 references indexed in Scilit:
- Risk estimation based on germ-cell mutations in animalsGenome, 1989
- Rates and survival of individuals with trisomy 13 and 18 Data from a 10‐year period in DenmarkClinical Genetics, 1988
- Genetic injury in hybrid male mice exposed to low doses of 60C γ-rays or fission neutrons I. Response to single dosesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1984
- Chromosome anomalies among livebirths.Journal of Medical Genetics, 1977
- Frequency of chromosomal abnormalities in miscarriages and perinatal deaths.Journal of Medical Genetics, 1977
- Re-analysis of radiation-induced specific locus mutations in the mouseNature, 1976
- B. Genetic Effects 2. Cytogenetic StudyJournal of Radiation Research, 1975
- CHROMOSOME ABNORMALITY AND: PERINATAL DEATHThe Lancet, 1974
- Determination of the radiation-induced mutation rate for sex-linked lethals and detrimentals in the mouseMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1972
- Estimates of the genetic risks from ionizing irradiationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1971