Camptocormia as a clinical manifestation of polymyositis/systemic sclerosis overlap myositis associated with anti-Ku
- 28 March 2012
- journal article
- case report
- Published by Springer Nature in Rheumatology International
- Vol. 33 (9) , 2411-2415
- https://doi.org/10.1007/s00296-012-2412-6
Abstract
Camptocormia, an abnormal truncal flexion posture that occurs while walking or standing, is usually caused by various hypokinetic movement disorders, mainly Parkinson disease. We describe the case of a man with subacute onset of camptocormia. Quadriceps muscle biopsy showed significant rhabdomyolysis, few isolated inflammatory cells and mild expression of type I MHC in few fibers, a pattern usually found in immune-mediated necrotizing myopathies. Myositis was associated with Raynaud’s phenomenon, mild sclerodactyly, and anti-Ku antibodies leading to the diagnosis of polymyositis/systemic sclerosis overlap myositis. The posture showed modest improvement in response to treatment.Keywords
This publication has 15 references indexed in Scilit:
- Comment faire le diagnostic et mieux comprendre les myopathies inflammatoires ? L’utilité des auto-anticorpsLa Presse Médicale, 2010
- Diagnostic performance and validation of autoantibody testing in myositis by a commercial line blot assayRheumatology, 2010
- Presentation, Etiology, Diagnosis, and Management of CamptocormiaEuropean Neurology, 2010
- Paraspinal and Scapular Myopathy Associated With SclerodermaJournal of Clinical Neuromuscular Disease, 2010
- Prevalence and clinical associations of anti-Ku antibodies in systemic autoimmune diseasesLupus, 2008
- Complete fatty degeneration of lumbar erector spinae muscles caused by a primary dysferlinopathyMuscle & Nerve, 2007
- Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomesArthritis Research & Therapy, 2007
- Response of the dropped head/bent spine syndrome to treatment with intravenous immunoglobulinMuscle & Nerve, 2006
- Camptocormia as a clinical manifestation of mitochondrial myopathyClinical Rheumatology, 2006
- Novel Classification of Idiopathic Inflammatory Myopathies Based on Overlap Syndrome Features and AutoantibodiesMedicine, 2005