Biosynthesis of the pigments of life: formation of the macrocycle
- 1 May 1980
- journal article
- Published by Springer Nature in Nature
- Vol. 285 (5759) , 17-21
- https://doi.org/10.1038/285017a0
Abstract
The organic nuclei of chlorophylls, haems, cytochromes and vitamin B12 are biosynthesised from a single tetrapyrrolic intermediate which has an unexpected, rearranged structure. The mechanism of biosynthesis of this key intermediate has now been characterised in detail. Some of the information thereby obtained is also of use in the investigation of human diseases such as the porphyrias.Keywords
This publication has 24 references indexed in Scilit:
- Mechanistic study of the enzymic incorporation of unrearranged AP·AP pyrromethane into uro'gen-IIIJournal of the Chemical Society, Chemical Communications, 1977
- Enzymic formation of the type-III prophyrin macrocycle from unrearranged AP·AP pyrromethaneJournal of the Chemical Society, Chemical Communications, 1977
- Biosynthesis of uroporphyrinogen III from porphobilinogen. Resolution of the enigmatic "switch" mechanismJournal of the American Chemical Society, 1976
- Biosynthesis of porphyrins and related macrocycles. Part VII. Synthesis of specifically labelled [14C1]uroporphyrin-III and of [10,14-13C2]uroporphyrin-III. Conversion of the latter into [10,14-13C2]protoporphyrin-IX; biosynthetic significance of its 13C nuclear magnetic resonance spectrumJournal of the Chemical Society, Perkin Transactions 1, 1976
- Biosynthesis of porphyrins and related macrocycles. Part VI. Nature of the rearrangement process leading to the natural type III porphyrinsJournal of the Chemical Society, Perkin Transactions 1, 1976
- Biosynthesis of type-III porphyrins: nature of the rearrangement processJournal of the Chemical Society, Chemical Communications, 1973
- Chemical and enzymic polymerization of 2-aminomethyl-3,3'-carboxymethyl-4,4'-(β-carboxyethyl)dipyrrylmethaneBiochemistry, 1973
- Intermediates in porphyrin biosynthesis: studies with 14C- and 13C-labelled pyrromethanesJournal of the Chemical Society, Chemical Communications, 1973
- Assignment of 13C-signals from the meso-carbons by syntheses of 13C-protoporphyrin-IX dimethyl estersJournal of the Chemical Society, Chemical Communications, 1973
- The enzymatic incorporation of a dipyrrylmethane into uroporphyrinogen IIIFEBS Letters, 1972