Evidence that brain prostaglandin synthesis is not essential in fever.

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Abstract
Whether a fever caused by pyrogen depends upon the synthesis of prostaglandin E [PGE] in the brain and if the PG in turn acts on the hypothalamus to produce fever was studied. In rabbits, fever was produced by the injection of leukocyte pyrogen in a lateral cerebral ventricle. The latency, rate of rise and magnitude of the fever was unaffected by the simultaneous intraventricular injection of 2 PG antagonists, SC 19220 [dibenzoxazepine derivative] and HR 546 [substituted prostaglandin A]. Both antagonists effectively attenuated the fever caused by the intraventricular injection of PGE2. This evidence is not consistent with the hypothesis that PGE is the principal mediator of fever.