Suppression of phosphorylcholine‐specific IgE antibody formation in BALB/c mice by isologous anti‐T 15 antiserum

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Abstract
In order to study the regulation of IgE antibody formation, isologous anti‐idiotypic antisera against the phosphoryl choline (PC)‐specific BALB/c myeloma proteins T15 and M167 were passively administered to BALB/c mice in the course of an anti‐PC IgE response. Isologous anti‐T 15 antiserum had a long‐lasting suppressive effect on the formation of IgE antibodies with PC specificity, whereas administration of anti‐ M167 antiserum had no or only little effect, similar to that of normal BALB/c serum. This indicates that anti‐PC IgE antibodies consist mainly of the T15 idiotype or of cross‐reacting idiotypes, and that IgE response is accessible to regulation with anti‐ idiotypic antibodies. This murine model may permit the study of regulation of an IgE response largely restricted to few defined idiotypes characterized as tumor proteins.