Synthesis of 2-[2-(Diphenylphosphino)ferrocenyl]oxazoline Ligands
- 1 January 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1995 (01) , 74-76
- https://doi.org/10.1055/s-1995-4864
Abstract
Dehydration of β-hydroxy amide 5, generated by condensation of (S)-(+)-valinol with ferrocenoyl chloride, gives (S)-2-ferrocenyl-4-(1-methylethyl)oxazoline 7. This is employed in the synthesis of (S)-2-[(S)-2-(diphenylphosphino)ferrocenyl]-4-(1-methylethyl)oxazoline 8 and the corresponding (S)-(R) diastereoisomer 9; a complementary pair of ligands for use in asymmetric catalysis.Keywords
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