Hexokinase, Jack-of-All-Trades
- 11 April 2003
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 300 (5617) , 261-263
- https://doi.org/10.1126/science.1084120
Abstract
Certain enzymes have dual functions having both catalytic and signaling activities. To this group can now be added plant hexokinases, as Frommer and colleagues discuss in their Perspective. Elegant work with Arabidopsis mutants reveals that plant hexokinases not only phosphorylate glucose but also sense glucose levels and participate in the glucose signaling pathway.Keywords
This publication has 10 references indexed in Scilit:
- Role of the Arabidopsis Glucose Sensor HXK1 in Nutrient, Light, and Hormonal SignalingScience, 2003
- Functional Characteristics of Hexokinase Bound to the Type A and Type B Sites of Bovine Brain MitochondriaArchives of Biochemistry and Biophysics, 2002
- Hexokinase PII: structural analysis and glucose signalling in the yeast Saccharomyces cerevisiaeYeast, 2001
- The High Resolution Crystal Structure of Yeast Hexokinase PII with the Correct Primary Sequence Provides New Insights into Its Mechanism of ActionJournal of Biological Chemistry, 2000
- Spinach hexokinase I is located in the outer envelope membrane of plastidsFEBS Letters, 1999
- A Novel NH2-terminal, Nonhydrophobic Motif Targets a Male Germ Cell-specific Hexokinase to the Endoplasmic Reticulum and Plasma MembraneJournal of Biological Chemistry, 1999
- The Dual Function of Sugar Carriers: Transport and Sugar SensingPlant Cell, 1999
- Is hexokinase really a sugar sensor in plants?Trends in Plant Science, 1999
- The hexokinase 2 protein participates in regulatory DNA‐protein complexes necessary for glucose repression of the SUC2 gene in Saccharomyces cerevisiaeFEBS Letters, 1998
- Co‐localization of glucokinase with actin filamentsFEBS Letters, 1997