IS ADHERENT, NONSPECIFIC SUPPRESSOR CELL FROM RODENT SPLEENS AN INVITRO ARTIFACT

  • 1 January 1978
    • journal article
    • research article
    • Vol. 32  (3) , 466-470
Abstract
Mitomycin C-treated cells from the spleens of mice pre-treated with BCG, Corynebacterium parvum [Propionibacterium acnes], cyclophosphamide or methylcellulose inhibited the mitogen responses of normal cells in vitro, but extended dose-response studies showed that such cell populations enhance the response if added in very small numbers. The number of cells giving peak enhancement was proportional to the percentage of the spleen cells which were adherent at 72 h. Such late-adhering cells are not removed by conventional adherence column techniques. The concept of the adherent suppressor T [thymus-derived] cell was discussed.