Acarbose Slows Progression of Intima-Media Thickness of the Carotid Arteries in Subjects With Impaired Glucose Tolerance
- 1 May 2004
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 35 (5) , 1073-1078
- https://doi.org/10.1161/01.str.0000125864.01546.f2
Abstract
Background and Purpose— Impaired glucose tolerance (IGT)–a prediabetic state–is an important risk factor for atherosclerosis. Acarbose, an α-glucosidase inhibitor, was shown in the placebo-controlled prospective study to prevent noninsulin-dependent diabetes mellitus (STOP-NIDDM) trial to reduce the risk of diabetes by 36% in IGT subjects. This article reports on a placebo-controlled subgroup analysis of the STOP-NIDDM study to examine the efficacy of acarbose to slow progression of intima-media thickness (IMT) in subjects with IGT.Keywords
This publication has 31 references indexed in Scilit:
- Postchallenge Hyperglycemia and Mortality in a National Sample of U.S. AdultsDiabetes Care, 2001
- Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stressDiabetologia, 2001
- Impaired glucose tolerance, Type II diabetes mellitus and carotid atherosclerosis: prospective results from the Bruneck StudyDiabetologia, 2000
- Glucose tolerance and mortality: comparison of WHO and American Diabetic Association diagnostic criteriaThe Lancet, 1999
- Postprandial plasma glucose is an independent risk factor for increased carotid intima-media thickness in non-diabetic individualsAtherosclerosis, 1999
- Impaired fasting glucose or impaired glucose tolerance. What best predicts future diabetes in Mauritius?Diabetes Care, 1999
- Carotid-Artery Intima and Media Thickness as a Risk Factor for Myocardial Infarction and Stroke in Older AdultsNew England Journal of Medicine, 1999
- The 1997 American Diabetes Association Criteria Versus the 1985 World Health Organization Criteria for the Diagnosis of Abnormal Glucose Tolerance: Poor agreement in the Hoorn StudyDiabetes Care, 1998
- Meal-Generated Oxidative Stress in Type 2 Diabetic PatientsDiabetes Care, 1998
- Prevalence of Carotid Atherosclerosis in Diabetic Patients Ultrasound high-resolution B-mode imaging on carotid arteriesDiabetes Care, 1992