Inhibitory Effect of Fluoride on Tooth Decalcification by Citrate and Lactate in Vivo

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Abstract
As little as 1 ppm. of F inhibited the erosion produced in rats'' molar teeth by 0.25 [image] Na citrate at pH 6.3-6.5 when incorporated in the latter and admd. to the rat as the sole source of drinking fluid. 50 ppm. of F was no more effective in inhibiting erosion than 5 ppm. Although intraperit. injd. fluoride was effective in reducing the erosion caused by citrate, about 25 times more fluoride was necessary to give the same effect produced by 1 ppm. of F orally administered. Analysis of the rats'' incisors and molar teeth for fluorine showed that although approximately five times more fluorine was incorporated in the teeth of the rats receiving 50 ppm. of F than in those receiving 5 ppm., the degree of inhibition produced was the same. Hence it appears that the degree of inhibition of erosion by fluoride is not related to its concn. in the dental tissues. 50 ppm. of F was no more effective than 5 ppm. in reducing the erosion produced by 0.25 [image] lactate solns. at pH 3-3.2 when incorporated in the latter admd. to the rat as the sole source of drinking fluid. As little as 1 ppm. was effective in reducing the erosion produced by 0.25 [image] lactate solns. at pH 4.5 and maximum protection against erosion was produced at 2.5 ppm. of F. F injd. intraperit. was ineffective in reducing the amt. of erosion produced by lactate at pH 3.