Inhibition of juvenile hormone III biosynthesis by fluoromevalonolactone and citronellyl phenyl imidazoles in isolated corpora allata from the cockroach Periplaneta americana

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Abstract
1‐Citronellyl‐5‐phenyl imidazole (1,5‐CPI), 1‐citronellyl‐4‐phenyl imidazole (1,4‐CPI) and 1‐citronellyl‐2‐phenyl imidazole (1,2‐CPI) were tested as inhibitors of JH‐III biosynthesis in vitro. 1,5‐CPI was found to be most active followed by 1,2‐CPI. The least active isomer was 1,4‐CPI. Inhibition of JH biosynthesis by 1,5‐CPI resulted in no significant accumulation of the epoxidation substrate methyl farnesoate, and piperonyl butoxide, a known microsomal epoxidase inhibitor, produced only a slight increase in methyl farnesoate. Topical application of fluoromevalonolactone resulted in reduced biosynthetic capability of subsequently excised corpora allata.